DTC 421 — Cylinder 1 – High Side to Low Side Open — International DT466E

Diagnostic reference for International DT466E (1996–2003) Navistar three-digit code 421. Focus on injector circuit diagnosis for cylinder 1 high-side to…

Updated October 15, 2026

What it means

The ECM detected an open between the high-side and low-side of the cylinder 1 injector driver circuit. On the DT466E HEUI system this is an injector-circuit fault for cylinder 1; codes 422-426 cover cylinders 2-6.1

Most likely causes

  1. Open or damaged injector coil on cylinder 1 — The injector solenoid winding is open, breaking the high-to-low side path the ECM monitors.1
  2. Corroded, loose, or damaged injector connector at cylinder 1 — Terminal fretting or moisture intrusion at the valve cover pass-through or injector pigtail creates an open in the high/low side circuit.1
  3. Chafed or broken wiring in the injector harness for cylinder 1 — Harness rub-through on the valve cover, bulkhead, or near the ECM can open the high-side or low-side wire to cylinder 1.1
  4. Faulty injector driver/ECM output for cylinder 1 bank — Internal ECM driver fault or connector pin issue for the cylinder 1 injector bank can appear as a high-to-low side open.2

How to diagnose

  1. Verify code with a scan tool or flash code read; confirm DTC 421 is active and note freeze-frame conditions.
  2. Inspect cylinder 1 injector connector and pigtail for corrosion, oil intrusion, bent pins, and proper seating; compare to adjacent cylinders.
  3. Perform a visual and wiggle test of the injector harness from the valve cover to the ECM, looking for chafing, heat damage, or oil saturation.
  4. Check injector circuit resistance/continuity at the ECM harness connector for cylinder 1 high-side to low-side per Navistar service specs; an open indicates wiring or injector fault.
  5. If wiring tests good, isolate the injector by disconnecting it and rechecking circuit resistance at the harness side; a persistent open points to harness/ECM, a restored path points to the injector.
  6. Inspect related injector driver codes (e.g., DTC 525) and cylinder contribution codes (DTC 461) for additional clues before condemning the ECM.

Parts and tools you may need

Tools you’ll need

Rough cost and difficulty

Likely repairPartsShop laborWho usually does it
Wiring or connector repair$10–$1001–4 hrsDIY with tools and a manual
Fuel injector (each)$250–$5001.5–3 hrsShop
Engine wiring harness section$100–$5002–5 hrsShop
ECM/PCM replacement (programmed)$600–$2,0001–3 hrsShop

Typical US independent-shop figures; labor runs about $140–$200 per hour (dealers charge more). Confirm the diagnosis before buying parts.

When to see a pro

If circuit tests are inconclusive, intermittent faults persist after harness repair, or ECM driver fault is suspected, have the system evaluated by a qualified diesel technician with Navistar diagnostic capability. Do not attempt high-pressure oil or injector removal without proper training and safety controls.

Check for recalls

Recalls are tied to your truck’s VIN, so check yours directly: enter the VIN at NHTSA’s recall lookup. Open safety recalls are repaired free at a dealer.

Sources


  1. Curated DTC seed — International DT466E (curated) ↩︎ ↩︎ ↩︎ ↩︎

  2. Curated DTC seed — International DT466E (curated) ↩︎